Journal of Pharmacological Sciences, 2005, Vol.99(1), pp.117-120
2005
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- Autor(en) / Beteiligte
- Titel
- Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in Mice
- Ist Teil von
- Journal of Pharmacological Sciences, 2005, Vol.99(1), pp.117-120
- Ort / Verlag
- Japan: Elsevier B.V
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer’s disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1 – 42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1 – 42).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1347-8613eISSN: 1347-8648DOI: 10.1254/jphs.sc0050105Titel-ID: cdi_doaj_primary_oai_doaj_org_article_f0e778d05bd24e088cb9b42faf77a3c0
- Format
- –
- Schlagworte
- Acetylcholine - metabolism, Acetylcholinesterase - metabolism, Aging - physiology, Amino Acids - administration & dosage, Amino Acids - pharmacology, amyloid beta protein, Amyloid beta-Peptides - antagonists & inhibitors, Animals, Brain - drug effects, Brain - enzymology, Brain Chemistry, cognitive enhancer, Growth Hormone - blood, Growth Hormone - pharmacology, growth hormone releaser, Male, Memory - drug effects, Memory Disorders - chemically induced, Memory Disorders - prevention & control, Mice, Mice, Inbred C57BL, Peptide Fragments - antagonists & inhibitors, Time Factors