Frontiers in neuroscience, 2018-08, Vol.12, p.520-520
2018
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- Autor(en) / Beteiligte
- Titel
- The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer's Disease
- Ist Teil von
- Frontiers in neuroscience, 2018-08, Vol.12, p.520-520
- Ort / Verlag
- Switzerland: Frontiers Research Foundation
- Erscheinungsjahr
- 2018
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1662-4548, 1662-453XeISSN: 1662-453XDOI: 10.3389/fnins.2018.00520Titel-ID: cdi_doaj_primary_oai_doaj_org_article_efc2fc8f0a5c4c5ebe738a8d79b69e66
- Format
- –
- Schlagworte
- Adenosine, Adenosine receptors, Age, Aging, Alzheimer's disease, Caffeine, Coffee, Cognitive ability, Consumption, Dementia, Epidemiology, Geriatrics, Life Sciences, Memory, Metabolism, Metabolites, Nervous system, Neurodegenerative diseases, Neurons and Cognition, Neuropathology, Neuroscience, Pathology, Peptides, Risk factors, Studies, Tau protein, Therapeutic applications, β-Amyloid