Details

Autor(en) / Beteiligte

• Egelston, Colt A
• Avalos, Christian
• Tu, Travis Y
• Simons, Diana L
• Jimenez, Grecia
• Jung, Jae Y
• Melstrom, Laleh
• Margolin, Kim
• Yim, John H
• Kruper, Laura
• Mortimer, Joanne
• Lee, Peter P

Titel

Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression

Ist Teil von

• Nature communications, 2018-10, Vol.9 (1), p.4297-11, Article 4297

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Functional CD8 T cells in human tumors play a clear role in clinical prognosis and response to immunotherapeutic interventions. PD-1 expression in T cells involved in chronic infections and tumors such as melanoma often correlates with a state of T-cell exhaustion. Here we interrogate CD8 tumor-infiltrating lymphocytes (TILs) from human breast and melanoma tumors to explore their functional state. Despite expression of exhaustion hallmarks, such as PD-1 expression, human breast tumor CD8 TILs retain robust capacity for production of effector cytokines and degranulation capacity. In contrast, melanoma CD8 TILs display dramatic reduction of cytokine production and degranulation capacity. We show that CD8 TILs from human breast tumors can potently kill cancer cells via bi-specific antibodies. Our data demonstrate that CD8 TILs in human breast tumors retain polyfunctionality, despite PD-1 expression, and suggest that they may be harnessed for effective immunotherapies.