Details

Autor(en) / Beteiligte

• Ke, Ming
• Shen, Hui
• Fan, Jintu
• Huang, Xing
• Zhou, Zongtan
• Chen, Xiaogang
• Hu, Dewen

Titel

Combining Resting-state fMRI and DTI Analysis for Early-onset Schizophrenia

Ist Teil von

• International journal of computational intelligence systems, 2009-12, Vol.2 (4), p.375-385

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2009

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• We combined measures of resting-state functional magnetic resonance imaging and diffusion tensor imaging (DTI) to investigate alterations of function-structure relationships in patients with early-onset schizophrenia. DTI analysis revealed reduced fractional anisotropy in right frontal white matter. Corresponding gray matter regions showed reduced functional connectivity with other regions in the brain in patients with early-onset schizophrenia, compared with healthy controls. Our results demonstrated abnormal function-structure relationships in early-onset schizophrenia, and supported the view that white matter lesions might disrupt the neural circuits between frontal regions and other brain regions, and affect the functional connectivity in the frontal cortex.