Details

Autor(en) / Beteiligte

• Bidar, Frank
• Monneret, Guillaume
• Berthier, Franck
• Lukaszewicz, Anne-Claire
• Venet, Fabienne

Titel

Lack of SARS-CoV-2-specific cellular response in critically ill COVID-19 patients despite apparent effective vaccination

Ist Teil von

• Critical care (London, England), 2022-06, Vol.26 (1), p.170-170, Article 170

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2022

Quelle

Springer Nature - Complete Springer Journals

Beschreibungen/Notizen

• Cellular response was assessed by T-cell proliferation assay and whole blood Interferon-Gamma Release Assay (IGRA) after stimulation with SARS-Cov-2 proteins [4]. Considering that an uncoordinated T cell and antibody responses have been associated with disease progression [5], the understanding of mechanisms sustaining incomplete vaccination (presence of IgG but lack of T cell response) remains of utmost importance. Immune response to three doses of mRNA SARS-CoV-2 vaccines in CD19-targeted chimeric antigen receptor T cell immunotherapy recipients.