Details

Autor(en) / Beteiligte

• Yakubu, Michael N
• Mwangi, Victor I
• Netto, Rebeca L A
• Alecrim, Maria G C
• Alves, Jessica R S
• Almeida, Anne C G
• Santos, Gabriel F
• Lima, Gesiane S
• Machado, Lucas S
• Koolen, Hector H F
• Guimarães, Tiago P
• Chaves, Andrea R
• Vaz, Boniek G
• Monteiro, Wuelton M
• Costa, Fabio T M
• Lacerda, Marcus V G
• Gardinassi, Luiz G
• de Melo, Gisely C

Titel

Host metabolomic responses in recurrent P. vivax malaria

Ist Teil von

• Scientific reports, 2024-03, Vol.14 (1), p.7249-7249

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC-MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax.