Details

Autor(en) / Beteiligte

• Nedeljković, Milica
• Tanić, Nikola
• Dramićanin, Tatjana
• Milovanović, Zorka
• Šušnjar, Snežana
• Milinković, Vedrana
• Vujović, Ivana
• Prvanović, Mirjana
• Tanić, Nasta

Titel

Importance of Copy Number Alterations of FGFR1 and C-MYC Genes in Triple Negative Breast Cancer

Ist Teil von

• Journal of medical biochemistry, 2019-03, Vol.38 (1), p.63-70

Ort / Verlag

Serbia: Sciendo

Erscheinungsjahr

2019

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Triple negative breast cancer (TNBC) is characterized by aggressive clinical course and is unresponsive to anti-HER2 and endocrine therapy. TNBC is difficult to treat and is often lethal. Given the need to find new targets for therapy we explored clinicopathological significance of copy number gain of and . Our aim was to determine the impact of and copy number gain on clinical course and outcome of TNBC. and gene copy number alterations were evaluated in 78 archive TNBC samples using TaqMan based quantitative real time PCR assays. 50% of samples had increased copy number. copy number gain was associated with TNBC in contrast to ER positive cancers. Our results showed significant correlation between copy number gain and high grade of TNBCs. This suggests that copy number could be an useful prognostic marker for TNBC patients. copy number gain was associated with high pTNM stage as well as lobular and medullary tumor subtypes. 43% of samples had increased copy number. No correlations between copy number gain and clinicopathological variables were observed. We identified copy number gain as a prognostic marker for TNBC. Our results indicate that may contribute to TNBC progression. We observed no significant association between and/or copy number status and patient survival.