Details

Autor(en) / Beteiligte

• Toombs-Ruane, Leah J.
• Marshall, Jonathan C.
• Benschop, Jackie
• Drinković, Dragana
• Midwinter, Anne C.
• Biggs, Patrick J.
• Grange, Zoë
• Baker, Michael G.
• Douwes, Jeroen
• Roberts, Mick G.
• French, Nigel P.
• Burgess, Sara A.

Titel

Extended-spectrum β-lactamase- and AmpC β-lactamase-producing Enterobacterales associated with urinary tract infections in the New Zealand community: a case-control study

Ist Teil von

• International journal of infectious diseases, 2023-03, Vol.128, p.325-334

Ort / Verlag

Canada: Elsevier Ltd

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• •No pet factor was found associated with extended-spectrum β-lactamase-/ AmpC β-lactamase-producing Enterobacterales urinary tract infection.•Risk factors included overseas travel, previous antibiotic use, and medical contact.•ST131 was the dominant sequence type among clinical isolates.•Genomic analysis of extended-spectrum β-lactamase-producing Escherichia coli suggested intercommunity transmission. To assess whether having a pet in the home is a risk factor for community-acquired urinary tract infections associated with extended-spectrum β-lactamase (ESBL)- or AmpC β-lactamase (ACBL)- producing Enterobacterales. An unmatched case-control study was conducted between August 2015 and September 2017. Cases (n = 141) were people with community-acquired urinary tract infection (UTI) caused by ESBL- or ACBL-producing Enterobacterales. Controls (n = 525) were recruited from the community. A telephone questionnaire on pet ownership and other factors was administered, and associations were assessed using logistic regression. Pet ownership was not associated with ESBL- or ACBL-producing Enterobacterales-related human UTIs. A positive association was observed for recent antimicrobial treatment, travel to Asia in the previous year, and a doctor's visit in the last 6 months. Among isolates with an ESBL-/ACBL-producing phenotype, 126/134 (94%) were Escherichia coli, with sequence type 131 being the most common (47/126). Companion animals in the home were not found to be associated with ESBL- or ACBL-producing Enterobacterales-related community-acquired UTIs in New Zealand. Risk factors included overseas travel, recent antibiotic use, and doctor visits.