Details

Autor(en) / Beteiligte

• Gündel, Beate
• Liu, Xinyuan
• Löhr, Matthias
• Heuchel, Rainer

Titel

Pancreatic Ductal Adenocarcinoma: Preclinical in vitro and ex vivo Models

Ist Teil von

• Frontiers in cell and developmental biology, 2021-10, Vol.9, p.741162-741162

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Pancreatic ductal adenocarcinoma (PDAC) is one of the most overlooked cancers despite its dismal median survival time of 6 months. The biggest challenges in improving patient survival are late diagnosis due to lack of diagnostic markers, and limited treatment options due to almost complete therapy resistance. The past decades of research identified the dense stroma and the complex interplay/crosstalk between the cancer- and the different stromal cells as the main culprits for the slow progress in improving patient outcome. For better simulation of this complex tumor microenvironment the models used in PDAC research likewise need to become more diverse. Depending on the focus of the investigation, several and models for PDAC have been established in the past years. Particularly, 3D cell culture such as spheroids and organoids have become more frequently used. This review aims to examine current PDAC models, their inherent limitations, and their successful implementations in research.