Details

Autor(en) / Beteiligte

• de la Fuente, Amanda
• Postigo, Tamara
• Sanus Ferri, Francisco
• Domínguez-Gil, Marta
• Álvarez-Manzanares, Jesús
• Eiros, Jose María
• Carbajosa Rodríguez, Virginia
• Sanchez Ramon, Susana
• Ortega, Alicia
• Fadrique Millán, Laura N.
• Vaquero-Roncero, Luis Mario
• Esteban-Velasco, Carmen
• Navarro-Matías, Elena
• Barbé, Ferran
• Bermejo-Martin, Jesús F.
• Lopez-Izquierdo, Raul

Titel

Synergistic impact of N-antigenemia profiled by a rapid antigen test and low anti-S1 antibodies on the risk of hospitalization in COVID-19

Ist Teil von

• International journal of infectious diseases, 2024-03, Vol.140, p.132-135

Ort / Verlag

Canada: Elsevier Ltd

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •There is a need for early detection of patients with COVID-19 who are at risk for hospitalization.•Concomitant profiling of viral and host parameters could help in this regard.•A positive rapid nucleocapsid-antigen test in plasma with low S1 antibodies predicts hospitalization. Identifying patients with COVID-19 who are at risk of poor evolution is key to early decide on their hospitalization. We evaluated the combined impact of nucleocapsid (N)-antigenemia profiled by a rapid test and antibodies against the S1 subunit of the SARS-CoV S protein (S1) on the hospitalization risk of patients with COVID-19. N-antigenemia and anti-S1 antibodies were profiled at admission to the emergency department in 146 patients with COVID-19 using the Panbio® antigen Rapid Test and the SARS-CoV-2 immunoglobulin G II Quant/SARS-CoV-2 immunoglobulin G assay from Abbott. A multivariable analysis was used to evaluate the impact of these factors on hospitalization. Patients with a positive N-antigen test in plasma and anti-S1 levels <2821 arbitrary units/mL needed hospitalization more frequently (20 of 23, 87%). A total of 20 of 71 (28.2%) of those showing a negative N-antigen test and anti-S1 ≥2821 arbitrary units/mL were hospitalized for 18 of 52 (34.6%) of the patients with only one of these conditions. Patients with a positive N-antigen test and low antibody levels showed an odds ratio, 95% confidence interval, and P-value for hospitalization of 18.21, 2.74-121.18, and 0.003, respectively, and exhibited the highest mortality (30.4%). Simultaneous profiling of a rapid N-antigen test in plasma and anti-S1 levels could help to early identify patients with COVID-19 needing hospitalization. [Display omitted]