Details

Autor(en) / Beteiligte

• Geng, Huixia
• Chen, Hongyang
• Wang, Haiying
• Wang, Lai
• Liu, Wei-Lin
• Wei-Lin Liu

Titel

The Histone Modifications of Neuronal Plasticity

Ist Teil von

• Neural plasticity, 2021-02, Vol.2021, p.6690523-7

Ort / Verlag

United States: Hindawi

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation, and ubiquitination, which change the three-dimensional structure of chromosomes and affect gene expression. Therefore, the combination of different states of histone modifications modulates gene expression is called histone code. The formation of learning and memory is one of the most important mechanisms for animals to adapt to environmental changes. A large number of studies have shown that histone codes are involved in the formation and consolidation of learning and memory. Here, we review the most recent literature of histone modification in regulating neurogenesis, dendritic spine dynamic, synapse formation, and synaptic plasticity.