Details

Autor(en) / Beteiligte

• Yazdani, Solmaz
• Seitz, Christina
• Cui, Can
• Lovik, Anikó
• Pan, Lu
• Piehl, Fredrik
• Pawitan, Yudi
• Kläppe, Ulf
• Press, Rayomand
• Samuelsson, Kristin
• Yin, Li
• Vu, Trung Nghia
• Joly, Anne-Laure
• Westerberg, Lisa S
• Evertsson, Björn
• Ingre, Caroline
• Andersson, John
• Fang, Fang

Titel

T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression

Ist Teil von

• Nature communications, 2022-11, Vol.13 (1), p.6733-13, Article 6733

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central nervous system. However, the contribution of T cell responses to the pathology of the disease is not fully understood. Here we show, by flow cytometric analysis of blood and cerebrospinal fluid (CSF) samples of a cohort of 89 newly diagnosed ALS patients in Stockholm, Sweden, that T cell phenotypes at the time of diagnosis are good predictors of disease outcome. High frequency of CD4 FOXP3 effector T cells in blood and CSF is associated with poor survival, whereas high frequency of activated regulatory T (Treg) cells and high ratio between activated and resting Treg cells in blood are associated with better survival. Besides survival, phenotypic profiling of T cells could also predict disease progression rate. Single cell transcriptomics analysis of CSF samples shows clonally expanded CD4 and CD8 T cells in CSF, with characteristic gene expression patterns. In summary, T cell responses associate with and likely contribute to disease progression in ALS, supporting modulation of adaptive immunity as a viable therapeutic option.