Molecules, 2008-02, Vol.13 (2), p.319-330
2008
Details
- Autor(en) / Beteiligte
- Titel
- Nitroalkanes as central reagents in the synthesis of spiroketals
- Ist Teil von
- Molecules, 2008-02, Vol.13 (2), p.319-330
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Nitroalkanes can be profitably employed as carbanionic precursors for the assembly of dihydroxy ketone frameworks, suitable for the preparation of spiroketals. The carbon-carbon bond formation is carried out exploiting nitroaldol and Michael reactions, while the nitro to carbonyl conversion (Nef reaction) ensures the correct introduction of the keto group. Several spiroketal systems endowed with considerable biological activity can be prepared using this synthetic strategy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules13020319Titel-ID: cdi_doaj_primary_oai_doaj_org_article_e6d0770fa7b54bf0bc276fe61fecca21
- Format
- –
- Schlagworte
- Alkanes - chemical synthesis, Alkanes - chemistry, Conjugate addition, Furans - chemical synthesis, Furans - chemistry, Indicators and Reagents, Nef reaction, Nitro Compounds - chemistry, nitroaldol reaction, nitroalkanes, Review, Spiro Compounds - chemical synthesis, Spiro Compounds - chemistry, spiroketals