Details

Autor(en) / Beteiligte

• Vignesh Chidambaram
• Nyan Lynn Tun
• Waqas Z Haque
• Marie Gilbert Majella
• Ranjith Kumar Sivakumar
• Amudha Kumar
• Angela Ting-Wei Hsu
• Izza A Ishak
• Aqsha A Nur
• Samuel K Ayeh
• Emmanuella L Salia
• Ahsan Zil-E-Ali
• Muhammad A Saeed
• Ayu P B Sarena
• Bhavna Seth
• Muzzammil Ahmadzada
• Eman F Haque
• Pranita Neupane
• Kuang-Heng Wang
• Tzu-Miao Pu
• Syed M H Ali
• Muhammad A Arshad
• Lin Wang
• Sheriza Baksh
• Petros C Karakousis
• Panagis Galiatsatos

Titel

Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis

Ist Teil von

• PloS one, 2020-01, Vol.15 (11), p.e0241541

Ort / Verlag

Public Library of Science (PLoS)

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• BackgroundUnderstanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and radiological factors associated with severity and mortality in COVID-19.MethodsWe searched PubMed, Embase and WHO database for English language articles from inception until May 8, 2020. We included Observational studies with direct comparison of clinical characteristics between a) patients who died and those who survived or b) patients with severe disease and those without severe disease. Data extraction and quality assessment were performed by two authors independently.ResultsAmong 15680 articles from the literature search, 109 articles were included in the analysis. The risk of mortality was higher in patients with increasing age, male gender (RR 1.45, 95%CI 1.23-1.71), dyspnea (RR 2.55, 95%CI 1.88-2.46), diabetes (RR 1.59, 95%CI 1.41-1.78), hypertension (RR 1.90, 95%CI 1.69-2.15). Congestive heart failure (OR 4.76, 95%CI 1.34-16.97), hilar lymphadenopathy (OR 8.34, 95%CI 2.57-27.08), bilateral lung involvement (OR 4.86, 95%CI 3.19-7.39) and reticular pattern (OR 5.54, 95%CI 1.24-24.67) were associated with severe disease. Clinically relevant cut-offs for leukocytosis(>10.0 x109/L), lymphopenia(< 1.1 x109/L), elevated C-reactive protein(>100mg/L), LDH(>250U/L) and D-dimer(>1mg/L) had higher odds of severe disease and greater risk of mortality.ConclusionKnowledge of the factors associated of disease severity and mortality identified in our study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.