Nutrition journal, 2017-10, Vol.16 (1), p.71-71, Article 71
2017
Details
- Autor(en) / Beteiligte
- Titel
- The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomized double-blind controlled trial
- Ist Teil von
- Nutrition journal, 2017-10, Vol.16 (1), p.71-71, Article 71
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- We evaluated the effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids enriched fish oil (FO) on nutritional and immunological parameters of treatment naïve breast cancer patients. In a randomized double blind controlled trial, the FO group (FG) patients were supplemented with 2 g/ day of FO concentrate containing 1.8 g of n-3 fatty acids during 30 days. The placebo group (PG) received 2 g/ day of mineral oil. At baseline and after the intervention, plasma levels of n-3 fatty acids, dietary intake, weight, body composition, biochemical and immunological markers were assessed. At the end of the intervention period, no between group differences were observed regarding anthropometric parameters. There was a significant increase in the plasma phospholipid EPA (p = 0.004), DHA (p = 0.007) of the FG patients. In FG patients the percentages of peripheral blood CD4 T lymphocytes and serum high sensitivity C-reactive protein (hsCRP) levels were maintained while in PG patients there was a significant increase in hsCRP (p = 0.024). We also observed a significant reduction in the percentage of CD4 T lymphocytes in the peripheral blood (p = 0.042) of PG patients. No changes in serum proinflammatory cytokine and prostaglandin E levels were observed. Supplementation of newly diagnosed breast cancer patients with EPA and DHA led to a significant change in the composition of plasma fatty acids, maintained the level of CD4 T cells and serum levels of hsCRP, suggestive of a beneficial effect on the immune system and less active inflammatory response. Brazilian Clinical Trials Registry (REBEC): RBR-2b2hqh. Registered 29 April 2013, retrospectively registered.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1475-2891eISSN: 1475-2891DOI: 10.1186/s12937-017-0295-9Titel-ID: cdi_doaj_primary_oai_doaj_org_article_e67022704d4b4e2886cf76000b4c1816
- Format
- –
- Schlagworte
- Adolescent, Adult, Aged, Analysis, Biomarkers - blood, Body composition, Breast cancer, Breast Neoplasms - blood, Breast Neoplasms - drug therapy, Breast Neoplasms - immunology, C-reactive protein, C-Reactive Protein - metabolism, Cancer therapies, Care and treatment, CD4 antigen, CD4-Positive T-Lymphocytes - cytology, Clinical trials, Cytokines, Cytokines - blood, Diagnosis, Diet, Dietary intake, Dietary supplements, Dinoprostone - blood, Docosahexaenoic Acids - administration & dosage, Docosahexaenoic Acids - blood, Double-Blind Method, Eicosapentaenoic acid (EPA), Eicosapentaenoic Acid - administration & dosage, Eicosapentaenoic Acid - blood, Fatty acids, Female, Fish oil, Fish oils, Fish Oils - administration & dosage, Humans, Immune system, Immunology, Immunonutrition, Inflammation, Laboratories, Lipids, Lymphocytes, Lymphocytes T, Metastasis, Middle Aged, Mineral oils, N-3 fatty acids, Nutrition, Nutritional Status, Patients, Peripheral blood, Phospholipids, Physiological aspects, Plasma levels, Prostaglandin E2, Serum levels, Socioeconomic Factors, Studies, Supplementation, Surgery, T cells, Tumor necrosis factor-TNF, Unsaturated fatty acids, Young Adult