Details

Autor(en) / Beteiligte

• Sato, Hiroe
• Takai, Chinatsu
• Kazama, Junichiro James
• Wakamatsu, Ayako
• Hasegawa, Eriko
• Kobayashi, Daisuke
• Kondo, Naoki
• Nakatsue, Takeshi
• Abe, Asami
• Ito, Satoshi
• Ishikawa, Hajime
• Kuroda, Takeshi
• Suzuki, Yoshiki
• Narita, Ichiei

Titel

Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

Ist Teil von

• Scientific reports, 2020-06, Vol.10 (1), p.9882-9882, Article 9882

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Hepcidin, a major regulator of iron metabolism and homeostasis, is regulated by inflammation. Recent studies have suggested that hepcidin and iron metabolism are involved in osteoporosis, and the aim of this study was to determine whether serum hepcidin levels are correlated with the degree of osteoporosis in patients with rheumatoid arthritis (RA). A total of 262 patients with RA (67.5 ± 11.4 years; 77.5% female) were enrolled. Serum iron, ferritin, and hepcidin levels were positively correlated each other. Multiple regression analyses revealed that the serum iron level was positively correlated with femoral T and Z scores, whereas the serum hepcidin level was not. Serum hepcidin level was correlated with the serum 25-hydroxy vitamin D level, which was in turn positively related to the femoral Z score. Serum hepcidin and serum iron were indirectly and directly related to osteoporosis in patients with RA.