Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7493
2021
Details
- Autor(en) / Beteiligte
- Titel
- Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication
- Ist Teil von
- Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7493
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- Electronic Journals Library
- Beschreibungen/Notizen
- Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin-monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules26247493Titel-ID: cdi_doaj_primary_oai_doaj_org_article_e5e7a134896b4c53a951294e02ba79f7
- Format
- –
- Schlagworte
- Alcohol, antiviral activity, Antiviral Agents - chemistry, Antiviral Agents - pharmacology, Chromatography, Conjugates, Coumarin, Coumarins - chemistry, Coumarins - pharmacology, Cytotoxicity, F protein, Hydrocarbons, Infant mortality, Influenza, Inhibitors, Microbial Sensitivity Tests, Models, Molecular, Molecular modelling, Molecular Structure, Monoterpenes - chemistry, Monoterpenes - pharmacology, Pneumonia, Respiratory syncytial virus, Respiratory Syncytial Virus, Human - drug effects, Serotypes, terpene, Vaccines, Virus Replication - drug effects, Viruses