Viruses, 2023-08, Vol.15 (8), p.1724
2023
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- Autor(en) / Beteiligte
- Titel
- Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis
- Ist Teil von
- Viruses, 2023-08, Vol.15 (8), p.1724
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2023
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Metabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of COVID-19 have gained significant attention during the pandemic. This review aimed to explore the genetic determinants associated with MAFLD, previously recognized as non-alcoholic fatty liver disease (NAFLD), and their potential influence on COVID-19 outcomes. Various genetic polymorphisms, including PNPLA3 (rs738409), GCKR (rs780094), TM6SF2 (rs58542926), and LYPLAL1 (rs12137855), have been investigated in relation to MAFLD susceptibility and progression. Genome-wide association studies and meta-analyses have revealed associations between these genetic variants and MAFLD risk, as well as their effects on lipid metabolism, glucose regulation, and liver function. Furthermore, emerging evidence suggests a possible connection between these MAFLD-associated polymorphisms and the severity of COVID-19. Studies exploring the association between indicated genetic variants and COVID-19 outcomes have shown conflicting results. Some studies observed a potential protective effect of certain variants against severe COVID-19, while others reported no significant associations. This review highlights the importance of understanding the genetic determinants of MAFLD and its potential implications for COVID-19 outcomes. Further research is needed to elucidate the precise mechanisms linking these genetic variants to disease severity and to develop gene profiling tools for the early prediction of COVID-19 outcomes. If confirmed as determinants of disease severity, these genetic polymorphisms could aid in the identification of high-risk individuals and in improving the management of COVID-19.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1999-4915eISSN: 1999-4915DOI: 10.3390/v15081724Titel-ID: cdi_doaj_primary_oai_doaj_org_article_e59d42abb7d74520b0c1d0128da2badc
- Format
- –
- Schlagworte
- Asymptomatic, Cardiovascular disease, Clinical outcomes, Comorbidity, COVID-19, COVID-19 - epidemiology, COVID-19 - genetics, Cytokines, Diabetes, Enzymes, Fatty liver, Gene polymorphism, Genes, Genetic aspects, Genetic diversity, Genetic polymorphisms, Genome-wide association studies, Genome-Wide Association Study, Genomes, Glucose metabolism, Humans, Hypertension, Infections, Lipid Metabolism, Liver diseases, MAFLD, Males, Medical research, Medicine, Experimental, Metabolism, Mortality, NAFLD, Non-alcoholic Fatty Liver Disease - epidemiology, Non-alcoholic Fatty Liver Disease - genetics, Obesity, Pandemics, Pathogenesis, PNPLA, Polymorphism, Prognosis, Review, Risk factors, rs738409, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Viral infections