Details

Autor(en) / Beteiligte

• Beisner, Julia
• Gonzalez-Granda, Anita
• Basrai, Maryam
• Damms-Machado, Antje
• Bischoff, Stephan C

Titel

Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases

Ist Teil von

• Nutrients, 2020-11, Vol.12 (11), p.3444

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• High consumption of fructose and high-fructose corn syrup is related to the development of obesity-associated metabolic diseases, which have become the most relevant diet-induced diseases. However, the influences of a high-fructose diet on gut microbiota are still largely unknown. We therefore examined the effect of short-term high-fructose consumption on the human intestinal microbiota. Twelve healthy adult women were enrolled in a pilot intervention study. All study participants consecutively followed four different diets, first a low fructose diet (< 10 g/day fructose), then a fruit-rich diet (100 g/day fructose) followed by a low fructose diet (10 g/day fructose) and at last a high-fructose syrup (HFS) supplemented diet (100 g/day fructose). Fecal microbiota was analyzed by 16S rRNA sequencing. A high-fructose fruit diet significantly shifted the human gut microbiota by increasing the abundance of the phylum , in which beneficial butyrate producing bacteria such as , and were elevated, and decreasing the abundance of the phylum including the genus . An HFS diet induced substantial differences in microbiota composition compared to the fruit-rich diet leading to a lower and a higher abundance as well as reduced abundance of the genus . Compared to a low-fructose diet we observed a decrease of and after the HFS diet. Abundance of positively correlated with plasma cholesterol and LDL level, whereas abundance of was negatively correlated. Different formulations of high-fructose diets induce distinct alterations in gut microbiota composition. High-fructose intake by HFS causes a reduction of beneficial butyrate producing bacteria and a gut microbiota profile that may affect unfavorably host lipid metabolism whereas high consumption of fructose from fruit seems to modulate the composition of the gut microbiota in a beneficial way supporting digestive health and counteracting harmful effects of excessive fructose.