Details

Autor(en) / Beteiligte

• Chang, Aeson
• Sloan, Erica K.
• Antoni, Michael H.
• Knight, Jennifer M.
• Telles, Rachel
• Lutgendorf, Susan K.

Titel

Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes

Ist Teil von

• Integrative Cancer Therapies, 2022, Vol.21, p.15347354221096081-15347354221096081

Ort / Verlag

Los Angeles, CA: SAGE Publications

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The relationship between psychosocial factors and cancer has intrigued people for centuries. In the last several decades there has been an expansion of mechanistic research that has revealed insights regarding how stress activates neuroendocrine stress-response systems to impact cancer progression. Here, we review emerging mechanistic findings on key pathways implicated in the effect of stress on cancer progression, including the cellular immune response, inflammation, angiogenesis, and metastasis, with a primary focus on the mediating role of the sympathetic nervous system. We discuss converging findings from preclinical and clinical cancer research that describe these pathways and research that reveals how these stress pathways may be targeted via pharmacological and mind-body based interventions. While further research is required, the body of work reviewed here highlights the need for and feasibility of an integrated approach to target stress pathways in cancer patients to achieve comprehensive cancer treatment.