Details

Autor(en) / Beteiligte

• Zhang, Linghong
• Li, Tao
• Yu, Yan
• Shi, Kun
• Bei, Zhongwu
• Qian, Yongjun
• Qian, Zhiyong

Titel

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

Ist Teil von

• Bioactive materials, 2023-02, Vol.20, p.339-354

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Myocardial infarction (MI) leads to massive cardiomyocyte death and deposition of collagen fibers. This fibrous tissue disrupts electrical signaling in the myocardium, leading to cardiac systolic and diastolic dysfunction, as well as arrhythmias. Conductive hydrogels are a promising therapeutic strategy for MI. Here, we prepared a highly water-soluble conductive material (GP) by grafting polypyrrole (PPy) onto non-conductive gelatin. This component was added to the gel system formed by the Schiff base reaction between oxidized xanthan gum (OXG) and gelatin to construct an injectable conductive hydrogel. The prepared self-healing OGGP3 (3 wt% GP) hydrogel had good biocompatibility, elastic modulus, and electrical conductivity that matched the natural heart. The prepared biomaterials were injected into the rat myocardial scar tissue 2 days after MI. We found that the cardiac function of the rats treated with OGGP3 was improved, making it more difficult to induce arrhythmias. The electrical resistivity of myocardial fibrous tissue was reduced, and the conduction velocity of myocardial tissue was increased. Histological analysis showed reduced infarct size, increased left ventricular wall thickness, increased vessel density, and decreased inflammatory response in the infarcted area. Our findings clearly demonstrate that the OGGP3 hydrogel attenuates ventricular remodeling and inhibits infarct dilation, thus showing its potential for the treatment of MI. [Display omitted] •An injectable self-healing conductive hydrogel was synthesized for the treatment of myocardial infarction (MI).•The OGGP3 hydrogel had elastic modulus (20.77 kPa) and conductivity (5.52 × 10−4 S/cm) that matched the natural heart.•The hydrogel could protect cardiac function, reduce arrhythmia susceptibility and the resistivity of cardiac scar tissue.•The hydrogel could increase left ventricular wall thickness, reduce infarct size and cardiac fibrosis in the infarcted area.•The hydrogel could promote the expression level of cardiac-specific markers, induce angiogenesis, and reduce inflammation.