Details

Autor(en) / Beteiligte

• Villemagne, Victor L
• Leuzy, Antoine
• Bohorquez, Sandra Sanabria
• Bullich, Santiago
• Shimada, Hitoshi
• Rowe, Christopher C
• Bourgeat, Pierrick
• Lopresti, Brian
• Huang, Kun
• Krishnadas, Natasha
• Fripp, Jurgen
• Takado, Yuhei
• Gogola, Alexandra
• Minhas, Davneet
• Weimer, Robby
• Higuchi, Makoto
• Stephens, Andrew
• Hansson, Oskar
• Doré, Vincent

Titel

CenTauR: Toward a universal scale and masks for standardizing tau imaging studies

Ist Teil von

• Alzheimer's & dementia : diagnosis, assessment & disease monitoring, 2023-07, Vol.15 (3), p.e12454-e12454

Ort / Verlag

United States: John Wiley & Sons, Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. One thousand forty-five participants underwent tau scans with either F-flortaucipir, F-MK6240, F-PI2620, F-PM-PBB3, F-GTP1, or F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)- subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauR , was constructed. None of the regions known to display off-target signal were included in the masks. The CenTauR allows robust discrimination between low and high levels of tau deposits. We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.