Details

Autor(en) / Beteiligte

• Guo, Hanfei
• Li, Wenqian
• Guo, Ye
• Chen, Naifei
• Cui, Jiuwei

Titel

Molecular classification of small cell lung cancer subtypes: Characteristics, prognostic factors, and clinical translation

Ist Teil von

• Chinese medical journal, 2024-01, Vol.137 (2), p.130-139

Ort / Verlag

China: Lippincott Williams & Wilkins Ovid Technologies

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Small cell lung cancer (SCLC) is a highly malignant tumor with a very poor prognosis; therefore, more effective treatments are urgently needed for patients afflicted with the disease. In recent years, emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology, metastasis, immune microenvironment, and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC phenotypes. Additionally, advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the disease. Herein, we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.