International journal of molecular sciences, 2020-05, Vol.21 (9), p.3344
2020
Details
- Autor(en) / Beteiligte
- Titel
- Mechanisms of Blood-Brain Barrier Dysfunction in Traumatic Brain Injury
- Ist Teil von
- International journal of molecular sciences, 2020-05, Vol.21 (9), p.3344
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United States with roughly two million TBIs occurring annually. Due to the spectrum of severity and heterogeneity in TBIs, investigation into the secondary injury is necessary in order to formulate an effective treatment. A mechanical consequence of trauma involves dysregulation of the blood-brain barrier (BBB) which contributes to secondary injury and exposure of peripheral components to the brain parenchyma. Recent studies have shed light on the mechanisms of BBB breakdown in TBI including novel intracellular signaling and cell-cell interactions within the BBB niche. The current review provides an overview of the BBB, novel detection methods for disruption, and the cellular and molecular mechanisms implicated in regulating its stability following TBI.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms21093344Titel-ID: cdi_doaj_primary_oai_doaj_org_article_e3553300c6e5498ab1cfea0b97548210
- Format
- –
- Schlagworte
- Amnesia, Animals, aquaporin, Aquaporins - metabolism, Astrocytes - metabolism, Blood-brain barrier, Blood-Brain Barrier - drug effects, Blood-Brain Barrier - metabolism, Blood-Brain Barrier - pathology, Blood-Brain Barrier - physiopathology, Blood–brain barrier disruption, Brain Edema - metabolism, Brain Edema - physiopathology, Brain Injuries, Traumatic - drug therapy, Brain Injuries, Traumatic - metabolism, Brain Injuries, Traumatic - physiopathology, Brain Injuries, Traumatic - therapy, Cell interactions, Consciousness, Cytokines - metabolism, Cytotoxicity, Disease Models, Animal, Edema, endothelial cells, Endothelial Cells - metabolism, Fainting, Head injuries, Hemorrhage, Heterogeneity, Humans, Inflammation - metabolism, Inflammation - pathology, Intracellular signalling, Magnetic resonance imaging, Molecular modelling, Mortality, Parenchyma, Permeability, Proteins, Review, TBI, Trauma, Traumatic brain injury, Values, vascular–astrocyte coupling