Details

Autor(en) / Beteiligte

• Elghareeb, Mona M.
• Elshopakey, Gehad E.
• Rezk, Shaymaa
• Ateya, Ahmed
• El-Ashry, Eman S.
• Shukry, Mustafa
• Ghamry, Heba I.
• Alotaibi, Badriyah S.
• Hashem, Nada M.A.

Titel

Nigella sativa oil restores hormonal levels, and endocrine signals among thyroid, ovarian, and uterine tissues of female Wistar rats following sodium fluoride toxicity

Ist Teil von

• Biomedicine & pharmacotherapy, 2024-01, Vol.170, p.116080-116080, Article 116080

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The current study aimed to explore the possible prophylactic and therapeutic effect of Nigella sativa L. oil (NSO) against disruption of endocrine signals and injuries in the thyroid gland, ovary, and uterine tissues induced by sodium fluoride (NaF). Twenty-eight mature female Wistar rats were randomly allocated into four experimental groups (n = 7/group) as follows: control group; NaF group, orally received NaF (20 mg/kg b.wt.) daily; NSO/NaF, orally received NSO (300 mg/kg b.wt.) two weeks before being given NaF and continued throughout the experiment; and NSO+NaF group orally received NSO concurrently with NaF. Our results indicated that NSO restored hormonal balance and suppressed oxidative damage and inflammation. Moreover, the levels of triiodothyronine, thyroxine, thyroid peroxidase, estrogen (E2), progesterone, follicle-stimulating hormone, and luteinizing hormone were elevated, while prostaglandins F2-α and cortisol levels were decreased in NSO treated groups compared to NaF-intoxicated rats. As well, NSO significantly boosted levels of antioxidant molecules, and lowered lipid peroxidation of examined tissues, unlike NaF-treated group. NSO also up-regulated antioxidant enzymes, anti-apoptotic protein, zona pellucida sperm-binding protein, bone morphogenetic protein, and thyroid stimulating hormone, conversely down-regulated inflammatory cytokines, apoptotic proteins, estrogen receptor-α, estrogen receptor-β, and thyroid stimulating hormone receptors compared to NaF-intoxicated group. Additionally, NSO ameliorated tissue damage of the thyroid gland, ovary, and uterus induced by NaF. -Overall, the prophylactic group (NSO/NaF) performed better antioxidant and anti-inflammatory activities than the treated group almost in all examined tissues, which is reflected by the improvement in the structure of the thyroid, ovarian, and uterine tissues. [Display omitted] •Sodium fluoride (NaF) caused hypothyroidism and reproductive dysfunction.•Nigella sativa L oil (NSO) possesses antioxidant potential toward NaF toxicity.•NSO enhances anti-inflammatory and antiapoptotic activity against NaF toxicity.•NSO upregulates ZP3, and Bmp15, while it downregulates TSHR and ER gene expression.•NSO improves thyroidal, ovarian, and uterine histological alterations.