Details

Autor(en) / Beteiligte

• Lynes, Matthew D.
• Shamsi, Farnaz
• Sustarsic, Elahu Gosney
• Leiria, Luiz O.
• Wang, Chih-Hao
• Su, Sheng-Chiang
• Huang, Tian Lian
• Gao, Fei
• Narain, Niven R.
• Chen, Emily Y.
• Cypess, Aaron M.
• Schulz, Tim J.
• Gerhart-Hines, Zachary
• Kiebish, Michael A.
• Tseng, Yu-Hua

Titel

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism

Ist Teil von

• Cell reports (Cambridge), 2018-07, Vol.24 (3), p.781-790

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure. [Display omitted] •We report lipid profiles of cold-exposed humans and mice by MS/MSALL shotgun lipidomics•We profiled circulating as well as brown and white adipose lipids in response to cold•We identified a bio-signature of cardiolipin biogenesis in cold humans and mice•We created an online tool to visualize changes of specific lipid species in our study In this resource, Lynes et al. use a sensitive MS/MSALL technique to profile over 1,000 lipid species in the blood and adipose tissue of humans and mice exposed to cold. Using the online viewer they created to view these data, pathways activated by cold exposure can be identified.