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In this study, the effects of variable characteristics amalgamated with chemical reaction and Arrhenius activation energy are analyzed on a two-dimensional (2D) electrically conducting radiative Casson nanoliquid flow past a deformable cylinder embedded in a porous medium. The surface of the cylinder is deformable in the radial direction i.e., the z-axis. The impression of Soret and Dufour's effects boosts the transmission of heat and mass. The flow is analyzed numerically with the combined impacts of momentum slip, convective heat, and mass conditions. A numerical solution for the system of the differential equations is attained by employing the bvp4c function in MATLAB. The dimensionless protuberant parameters are graphically illustrated and discussed for the involved profiles. It is perceived that on escalating the velocity slip parameter and porosity parameter velocity field depreciates. Also, on escalating the radiation parameter and heat transfer Biot number a prominent difference is noticed in an upsurge of the thermal field. For growing values of Brownian motion and thermophoretic parameters, temperature field augments. On escalating the curvature parameter and porosity parameter, drag force coefficient upsurges. The outcome of the Soret number, mass transfer Biot number, and activation energy parameter is quite eminent on the concentration distribution for the sheet in comparison to the deformable cylinder. A comparative analysis of the present investigation with an already published work is also added to substantiate the envisioned problem.