Details

Autor(en) / Beteiligte

• Dittmar, Katharina
• de Souza, Sheila Mendonça
• Araújo, Adauto

Titel

Challenges of phylogenetic analyses of aDNA sequences

Ist Teil von

• Memórias do Instituto Oswaldo Cruz, 2006-12, Vol.101 Suppl 2 (suppl 2), p.9-13

Ort / Verlag

Brazil: Instituto Oswaldo Cruz, Ministério da Saúde

Erscheinungsjahr

2006

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• One of the crucial steps of authentication of aDNA sequences is phylogenetic consistency. Amplified sequences should fit into the phylogenetic framework of their supposed origin. An inherent property of aDNA sequences however, is their short sequence length. Additionally, genes for aDNA studies are often chosen by their preservation potential rather than by phylogenetically informative content. This poses potential challenges regarding their analyses, and might result in an inaccurate reflection of the supposed phylogenetic history of the sequence or organism under study. In this paper some fundamental problems of phylogenetic analysis and interpretation of aDNA datasets are discussed. Suggestions for character sampling and treatment of missing data are made. The publication is the result of a talk from the 1st PAMINSA Meeting in Rio de Janeiro, July 2005.