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Activation of the RIG-I/MAVS Signaling Pathway during Human Adenovirus Type 3 Infection Impairs the Pro-Inflammatory Response Induced by Secondary Infection with Staphylococcus aureus
Ist Teil von
International journal of molecular sciences, 2024-04, Vol.25 (8), p.4178
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2024
Link zum Volltext
Quelle
Electronic Journals Library
Beschreibungen/Notizen
The exacerbation of pneumonia in children with human adenovirus type 3 (HAdV-3E) is secondary to a
(
) infection. The influence of host-pathogen interactions on disease progression remains unclear. It is important to note that
infections following an HAdV-3E infection are frequently observed in clinical settings, yet the underlying susceptibility mechanisms are not fully understood. This study utilized an A549 cell model to investigate secondary infection with
following an HAdV-3E infection. The findings suggest that HAdV-3E exacerbates the
infection by intensifying lung epithelial cell damage. The results highlight the role of HAdV-3E in enhancing the interferon signaling pathway through
(
), resulting in the increased expression of interferon-stimulating factors like
,
, and
. The increase in interferon-stimulating factors inhibits the NF-κB and MAPK/P38 pro-inflammatory signaling pathways. These findings reveal new mechanisms of action for HAdV-3E and
in secondary infections, enhancing our comprehension of pathogenesis.