Details

Autor(en) / Beteiligte

• Yajima, Ichiro
• Kumasaka, Mayuko Y.
• Thang, Nguyen Dinh
• Goto, Yuji
• Takeda, Kozue
• Iida, Machiko
• Ohgami, Nobutaka
• Tamura, Haruka
• Yamanoshita, Osamu
• Kawamoto, Yoshiyuki
• Furukawa, Keiko
• Kato, Masashi
• Chun, Kyung-Soo

Titel

Molecular Network Associated with MITF in Skin Melanoma Development and Progression

Ist Teil von

• Journal of Skin Cancer, 2011-01, Vol.2011, p.730170-7

Ort / Verlag

United States: Hindawi Limiteds

Erscheinungsjahr

2011

Quelle

Elektronische Zeitschriftenbibliothek

Beschreibungen/Notizen

• Various environmental and genetic factors affect the development and progression of skin cancers including melanoma. Melanoma development is initially triggered by environmental factors including ultraviolet (UV) light, and then genetic/epigenetic alterations occur in skin melanocytes. These first triggers alter the conditions of numerous genes and proteins, and they induce and/or reduce gene expression and activate and/or repress protein stability and activity, resulting in melanoma progression. Microphthalmia-associated transcription factor (MITF) is a master regulator gene of melanocyte development and differentiation and is also associated with melanoma development and progression. To find better approaches to molecular-based therapies for patients, understanding MITF function in skin melanoma development and progression is important. Here, we review the molecular networks associated with MITF in skin melanoma development and progression.