Nature communications, 2018-09, Vol.9 (1), p.3691-13, Article 3691
2018
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- Autor(en) / Beteiligte
- Titel
- Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system
- Ist Teil von
- Nature communications, 2018-09, Vol.9 (1), p.3691-13, Article 3691
- Ort / Verlag
- London: Nature Publishing Group UK
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Spiral ganglion (SG) neurons of the cochlea convey all auditory inputs to the brain, yet the cellular and molecular complexity necessary to decode the various acoustic features in the SG has remained unresolved. Using single-cell RNA sequencing, we identify four types of SG neurons, including three novel subclasses of type I neurons and the type II neurons, and provide a comprehensive genetic framework that define their potential synaptic communication patterns. The connectivity patterns of the three subclasses of type I neurons with inner hair cells and their electrophysiological profiles suggest that they represent the intensity-coding properties of auditory afferents. Moreover, neuron type specification is already established at birth, indicating a neuronal diversification process independent of neuronal activity. Thus, this work provides a transcriptional catalog of neuron types in the cochlea, which serves as a valuable resource for dissecting cell-type-specific functions of dedicated afferents in auditory perception and in hearing disorders. Spiral ganglion neurons (SGNs) of the cochlea receive input from hair cells and project to the auditory brainstem. Here, the authors perform single-cell RNA sequencing to identify four SGN subclasses and characterize their molecular profile, electrophysiological properties and connectivity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-018-06033-3Titel-ID: cdi_doaj_primary_oai_doaj_org_article_e0bef93908bf44c3ab6cf59e4b184569
- Format
- –
- Schlagworte
- 13/51, 38, 38/32, 38/91, 631/114, 631/378/2619/1387, 631/80, 64/110, Animals, Auditory perception, Brain, Cochlea, Cochlea - cytology, Cochlea - metabolism, Gene sequencing, Hair cells, Hair Cells, Auditory - cytology, Hair Cells, Auditory - metabolism, Hair Cells, Auditory, Inner - cytology, Hair Cells, Auditory, Inner - metabolism, Heterogeneity, Humanities and Social Sciences, Life Sciences, Medicin och hälsovetenskap, multidisciplinary, Neural networks, Neurons, Neurons - cytology, Neurons - metabolism, Neurons and Cognition, Neurons, Afferent - cytology, Neurons, Afferent - metabolism, Ribonucleic acid, RNA, Science, Science (multidisciplinary), Sensory neurons, Sequence Analysis, RNA, Single-Cell Analysis, Spiral ganglion, Spiral Ganglion - cytology, Spiral Ganglion - metabolism, Synaptic Potentials - physiology, Transcription