Details

Autor(en) / Beteiligte

• Tamura, Tomokazu
• Ito, Jumpei
• Uriu, Keiya
• Zahradnik, Jiri
• Kida, Izumi
• Anraku, Yuki
• Nasser, Hesham
• Shofa, Maya
• Oda, Yoshitaka
• Lytras, Spyros
• Nao, Naganori
• Itakura, Yukari
• Deguchi, Sayaka
• Suzuki, Rigel
• Wang, Lei
• Begum, MST Monira
• Kita, Shunsuke
• Yajima, Hisano
• Sasaki, Jiei
• Sasaki-Tabata, Kaori
• Shimizu, Ryo
• Tsuda, Masumi
• Kosugi, Yusuke
• Fujita, Shigeru
• Pan, Lin
• Sauter, Daniel
• Yoshimatsu, Kumiko
• Suzuki, Saori
• Asakura, Hiroyuki
• Nagashima, Mami
• Sadamasu, Kenji
• Yoshimura, Kazuhisa
• Yamamoto, Yuki
• Nagamoto, Tetsuharu
• Schreiber, Gideon
• Maenaka, Katsumi
• Hashiguchi, Takao
• Ikeda, Terumasa
• Fukuhara, Takasuke
• Saito, Akatsuki
• Tanaka, Shinya
• Matsuno, Keita
• Takayama, Kazuo
• Sato, Kei

Titel

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

Ist Teil von

• Nature communications, 2023-05, Vol.14 (1), p.2800-20, Article 2800

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions. XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant’s origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.