Details

Autor(en) / Beteiligte

• Zhang, Xue-Ping
• Pei, Jun-Peng
• Zhang, Chun-Dong
• Yusupu, Maimaititusun
• Han, Ming-Hao
• Dai, Dong-Qiu

Titel

Exosomal circRNAs: A key factor of tumor angiogenesis and therapeutic intervention

Ist Teil von

• Biomedicine & pharmacotherapy, 2022-12, Vol.156, p.113921-113921, Article 113921

Ort / Verlag

Elsevier Masson SAS

Erscheinungsjahr

2022

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Over the last few decades, our understanding of the molecular mechanisms underlying tumor angiogenesis has advanced at a significant pace and the clinical translation of these mechanisms has benefited millions of patients. However, limited efficacy and the rapid expansion of drug resistance remain unresolved issues. Recent studies in both preclinical and clinical settings have revealed that circRNAs, as a novel identified non-coding RNA can mediate intercellular communication and regulate the microenvironment within tumors after being selectively packaged, secreted, and transmitted via exosomes. This review aims to provide a comprehensive understanding of how exosomal circRNAs orchestrate inducers and inhibitors of angiogenesis, including their functions, molecular mechanisms, and potential roles as diagnostic biomarkers and therapeutic targets. Finally, we discuss the technological advances in exosome functionalization and exosome-mimetic nanovesicles intending to improve the clinical translation of exosomal circRNAs. [Display omitted] •Exosomal circRNAs regulate countervailing factors that either induce or oppose tumor angiogenesis.•Exosomal circRNAs possess natural advantages and great potential to act as diagnostic and prognostic biomarkers.•Exosome­based nanoplatforms can help to broaden the therapeutic capability of exosomal circRNAs.