Details

Autor(en) / Beteiligte

• Alaimo, Alessandro
• Lorenzoni, Marco
• Ambrosino, Paolo
• Bertossi, Arianna
• Bisio, Alessandra
• Macchia, Alice
• Zoni, Eugenio
• Genovesi, Sacha
• Cambuli, Francesco
• Foletto, Veronica
• De Felice, Dario
• Soldovieri, Maria Virginia
• Mosca, Ilaria
• Gandolfi, Francesco
• Brunelli, Matteo
• Petris, Gianluca
• Cereseto, Anna
• Villarroel, Alvaro
• Thalmann, George
• Carbone, Francesco Giuseppe
• Kruithof-de Julio, Marianna
• Barbareschi, Mattia
• Romanel, Alessandro
• Taglialatela, Maurizio
• Lunardi, Andrea

Titel

Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

Ist Teil von

• Cell death & disease, 2020-12, Vol.11 (12), p.1039-17, Article 1039

Ort / Verlag

England: Springer Nature B.V

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer treatment. Here, we demonstrate that selective agonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), a cation channel characteristic of the prostate epithelium frequently overexpressed in advanced stage III/IV prostate cancers (PCa), sensitize therapy refractory models of PCa to radio, chemo or hormonal treatment. Overall, our study demonstrates that pharmacological-induced Ca cytotoxicity is an actionable strategy to sensitize cancer cells to standard therapies.