Details

Autor(en) / Beteiligte

• Wang, Jing
• Huang, Haoyu
• Liu, Chunming
• Zhang, Yangping
• Wang, Wenjuan
• Zou, Zhuo
• Yang, Lei
• He, Xuemei
• Wu, Jinting
• Ma, Jing
• Liu, Yun

Titel

Research Progress on the Role of Vitamin D in Autism Spectrum Disorder

Ist Teil von

• Frontiers in behavioral neuroscience, 2022-05, Vol.16, p.859151-859151

Ort / Verlag

Switzerland: Frontiers Research Foundation

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can lead to severe social behavioral difficulties, which mainly manifests as social communication and interaction disorders; narrow interests; and repetitive, stereotyped behaviors. In recent years, the prevalence of ASD has increased annually, and it has evolved from a rare disease to one with a high incidence among childhood developmental disorders. The pathogenesis of ASD is considered to be the interaction of genetic and environmental factors. There is increasing evidence that vitamin D deficiency in pregnancy and early childhood can lead to the occurrence of ASD. Studies have demonstrated that vitamin D intervention can significantly improve the symptoms of ASD, but the underlying mechanism is still unclear. Therefore, exploring the neuroprotective mechanism of vitamin D against ASD is a huge challenge currently being worked on by current basic and clinical researchers, a task which is of great significance for the clinical promotion and optimization of vitamin D in the treatment of ASD. To further clarify the relationship between vitamin D and ASD, this review summarizes the correlation between vitamin D level and ASD, the effects of vitamin D supplementation on ASD, the possible mechanism of vitamin D involved in ASD, and insights from ASD animal models.