Details

Autor(en) / Beteiligte

• Stamatelopoulos, Kimon
• Georgiopoulos, Georgios
• Baker, Kenneth F.
• Tiseo, Giusy
• Delialis, Dimitrios
• Lazaridis, Charalampos
• Barbieri, Greta
• Masi, Stefano
• Vlachogiannis, Nikolaos I.
• Sopova, Kateryna
• Mengozzi, Alessandro
• Ghiadoni, Lorenzo
• van der Loeff, Ina Schim
• Hanrath, Aidan T.
• Ajdini, Bajram
• Vlachopoulos, Charalambos
• Dimopoulos, Meletios A.
• Duncan, Christopher J. A.
• Falcone, Marco
• Stellos, Konstantinos
• Monzani, Fabio
• Menichetti, Francesco
• Virdis, Agostino
• Forfori, Francesco
• Rubia, Baldassarri
• Pietro, Bertini
• Giulia, Brizzi
• Francesco, Corradi
• Alessandra, Della Rocca
• Fabio, Guarracino
• Paolo, Malacarne
• Marco, Monfroni
• Chiara, Piagnani
• Naria, Park
• Alessandro, Celi
• Carrozzi, Laura
• Francesco, Cinotti
• Santini, Massimo
• Alessandro, Cipriano
• Martina, Biancalana
• Matteo, Borselli
• Elia, Nencini
• Stefano, Spinelli
• Francesca, Ruberti
• Giovanna, Forotti
• Maria, Sciuto
• De Marco, Salvatore
• Rachele, Antognoli
• Valeria, Calsolario
• Simone, Paterni
• Luciano, Colangelo
• Chiara, Sonato
• Valentina, Galfo
• Uliana, Monica
• Tee, Su Ann
• Capstick, Richard
• Marchitelli, Gabriella
• Li, Ang
• Barr, Andrew
• Eid, Alsafi
• Ahmed, Sajeel
• Bajwa, Dalvir
• Mohammed, Omer

Titel

Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

Ist Teil von

• Scientific reports, 2021-10, Vol.11 (1), p.20239-20239, Article 20239

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Accurate risk stratification in COVID-19 patients consists a major clinical need to guide therapeutic strategies. We sought to evaluate the prognostic role of estimated pulse wave velocity (ePWV), a marker of arterial stiffness which reflects overall arterial integrity and aging, in risk stratification of hospitalized patients with COVID-19. This retrospective, longitudinal cohort study, analyzed a total population of 1671 subjects consisting of 737 hospitalized COVID-19 patients consecutively recruited from two tertiary centers (Newcastle cohort: n = 471 and Pisa cohort: n = 266) and a non-COVID control cohort (n = 934). Arterial stiffness was calculated using validated formulae for ePWV. ePWV progressively increased across the control group, COVID-19 survivors and deceased patients (adjusted mean increase per group 1.89 m/s, P  < 0.001). Using a machine learning approach, ePWV provided incremental prognostic value and improved reclassification for mortality over the core model including age, sex and comorbidities [AUC (core model + ePWV vs. core model) = 0.864 vs. 0.755]. ePWV provided similar prognostic value when pulse pressure or hs-Troponin were added to the core model or over its components including age and mean blood pressure ( p  < 0.05 for all). The optimal prognostic ePWV value was 13.0 m/s. ePWV conferred additive discrimination (AUC: 0.817 versus 0.779, P  < 0.001) and reclassification value (NRI = 0.381, P  < 0.001) over the 4C Mortality score, a validated score for predicting mortality in COVID-19 and the Charlson comorbidity index. We suggest that calculation of ePWV, a readily applicable estimation of arterial stiffness, may serve as an additional clinical tool to refine risk stratification of hospitalized patients with COVID-19 beyond established risk factors and scores.