Neurobiology of disease, 2008-08, Vol.31 (2), p.278-285
2008
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- Autor(en) / Beteiligte
- Titel
- Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress
- Ist Teil von
- Neurobiology of disease, 2008-08, Vol.31 (2), p.278-285
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0969-9961eISSN: 1095-953XDOI: 10.1016/j.nbd.2008.05.003Titel-ID: cdi_doaj_primary_oai_doaj_org_article_de69a8324e274ae8b050e301275e04c9
- Format
- –
- Schlagworte
- Animals, Antidepressant, Brain - drug effects, Brain - enzymology, Chronic Disease, CREB, Cyclic AMP Response Element-Binding Protein - drug effects, Cyclic AMP Response Element-Binding Protein - metabolism, Depressive Disorder - drug therapy, Depressive Disorder - enzymology, Depressive Disorder - physiopathology, Disease Models, Animal, Down-Regulation - drug effects, Down-Regulation - physiology, ERK, Extracellular Signal-Regulated MAP Kinases - drug effects, Extracellular Signal-Regulated MAP Kinases - metabolism, Fluoxetine - pharmacology, Hippocampus, Male, MAP Kinase Signaling System - drug effects, MAP Kinase Signaling System - physiology, Neurology, Phosphorylation - drug effects, Prefrontal cortex, Rats, Rats, Sprague-Dawley, Serotonin Uptake Inhibitors - pharmacology, Stress, Stress, Psychological - drug therapy, Stress, Psychological - enzymology, Stress, Psychological - physiopathology, Swimming - psychology, Up-Regulation - drug effects, Up-Regulation - physiology