Details

Autor(en) / Beteiligte

• Uscanga-Palomeque, Ashanti Concepción
• Chávez-Escamilla, Ana Karina
• Alvizo-Báez, Cynthia Aracely
• Saavedra-Alonso, Santiago
• Terrazas-Armendáriz, Luis Daniel
• Tamez-Guerra, Reyes S
• Rodríguez-Padilla, Cristina
• Alcocer-González, Juan Manuel

Titel

CAR-T Cell Therapy: From the Shop to Cancer Therapy

Ist Teil von

• International journal of molecular sciences, 2023-11, Vol.24 (21), p.15688

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Cancer is a worldwide health problem. Nevertheless, new technologies in the immunotherapy field have emerged. Chimeric antigen receptor (CAR) technology is a novel biological form to treat cancer; CAR-T cell genetic engineering has positively revolutionized cancer immunotherapy. In this paper, we review the latest developments in CAR-T in cancer treatment. We present the structure of the different generations and variants of CAR-T cells including TRUCK (T cells redirected for universal cytokine killing. We explain the approaches of the CAR-T cells manufactured ex vivo and in vivo. Moreover, we describe the limitations and areas of opportunity for this immunotherapy and the current challenges of treating hematological and solid cancer using CAR-T technology as well as its constraints and engineering approaches. We summarize other immune cells that have been using CAR technology, such as natural killer (NK), macrophages (M), and dendritic cells (DC). We conclude that CAR-T cells have the potential to treat not only cancer but other chronic diseases.