Details

Autor(en) / Beteiligte

• Rodrigues, Luiz Eduardo
• Kishibe, Milena Miyoshi
• Keller, Rogeria
• Caetano, Heliard Rodrigues Dos Santos
• Rufino, Marcos Natal
• Sanches, Osimar de Carvalho
• Giometti, Ines Cristina
• Giuffrida, Rogério
• Bremer-Neto, Hermann

Titel

Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study

Ist Teil von

• Veterinary World, 2021-05, Vol.14 (5), p.1210-1219

Ort / Verlag

India: Veterinary World

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• The prebiotics, mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the brain-intestinal axis, including maintaining male reproductive function and spermatogenesis and regulating stress. The aim of the present study was to evaluate the action of MOS on testosterone and corticosterone concentrations and the reproductive system development of rats in the growth phase as an animal model. In total, 128 male rats were used, randomly divided into four experimental groups (n=32): Control; MOS 1; MOS 2; and MOS 3. From each group, eight animals were sacrificed in four experimental moments (14, 28, 42, and 56 days, respectively, moments 1, 2, 3, and 4) and hormonal measurements and histological evaluations were performed. The results revealed the effect of diet, MOS, and timing on testicle weight (p<0.05). At moments 3 and 4, the groups supplemented with MOS showed higher concentrations of testosterone and decreased corticosterone levels throughout the experimental period. Groups supplemented with MOS showed an increase in the frequency of relative sperm and sperm scores. The radii of the seminiferous tubules presented a significant statistical effect of the diet, moments, and diet + moment interaction. It was concluded that the three different MOS prebiotics brought forward sexual maturity.