Details

Autor(en) / Beteiligte

• Liu, Dan-Dan
• Zhang, Chao-Yang
• Zhang, Jing-Ting
• Gu, Li-Min
• Xu, Guo-Tong
• Zhang, Jing-Fa

Titel

Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface

Ist Teil von

• Neural regeneration research, 2023-07, Vol.18 (7), p.1441-1449

Ort / Verlag

India: Wolters Kluwer India Pvt. Ltd

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Epigenetics focuses on DNA methylation, histone modification, chromatin remodeling, noncoding RNAs, and other gene regulation mechanisms beyond the DNA sequence. In the past decade, epigenetic modifications have drawn more attention as they participate in the development and progression of diabetic retinopathy despite tight control of glucose levels. The underlying mechanisms of epigenetic modifications in diabetic retinopathy still urgently need to be elucidated. The diabetic condition facilitates epigenetic changes and influences target gene expression. In this review, we summarize the involvement of epigenetic modifications and metabolic memory in the development and progression of diabetic retinopathy and propose novel insights into the treatment of diabetic retinopathy.