eLife, 2014-11, Vol.3, p.e04499-e04499
2014
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- Autor(en) / Beteiligte
- Titel
- Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness
- Ist Teil von
- eLife, 2014-11, Vol.3, p.e04499-e04499
- Ort / Verlag
- England: eLife Sciences Publications Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness. By using a novel combination of positron emission tomography and functional magnetic resonance imaging, we studied anesthesia-induced unconsciousness and recovery using the α₂-agonist dexmedetomidine. During unconsciousness, cerebral metabolic rate of glucose and cerebral blood flow were preferentially decreased in the thalamus, the Default Mode Network (DMN), and the bilateral Frontoparietal Networks (FPNs). Cortico-cortical functional connectivity within the DMN and FPNs was preserved. However, DMN thalamo-cortical functional connectivity was disrupted. Recovery from this state was associated with sustained reduction in cerebral blood flow and restored DMN thalamo-cortical functional connectivity. We report that loss of thalamo-cortical functional connectivity is sufficient to produce unconsciousness.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2050-084XeISSN: 2050-084XDOI: 10.7554/elife.04499Titel-ID: cdi_doaj_primary_oai_doaj_org_article_dc43095ecda0472b99af136234b879fc
- Format
- –
- Schlagworte
- Adolescent, Adult, Analgesics, Non-Narcotic - pharmacology, Anesthesia, Blood flow, Brain Mapping, Brain research, Cerebral blood flow, Cerebral Cortex - blood supply, Cerebral Cortex - drug effects, Cerebral Cortex - physiology, Consciousness, Consciousness - physiology, Cortex, cortico-cortical, default mode network, dexmedetomidine, Dexmedetomidine - pharmacology, Electroencephalography, Eye movements, Female, functional connectivity, Functional magnetic resonance imaging, Hospitals, Humans, Male, Medical imaging, Metabolic rate, Metabolism, Nerve Net - blood supply, Nerve Net - drug effects, Nerve Net - physiology, Nervous system, Neural networks, Neural Pathways - blood supply, Neural Pathways - drug effects, Neural Pathways - physiology, Neuroscience, NMR, Nuclear magnetic resonance, Positron emission tomography, Recovery of function, Sleep, thalamo-cortical, Thalamus, Thalamus - blood supply, Thalamus - drug effects, Thalamus - physiology, Unconsciousness - chemically induced, Unconsciousness - physiopathology