Details

Autor(en) / Beteiligte

• Goncharenko, Aleksandr A
• Tarasyuk, Ilya A
• Marfin, Yuriy S
• Grzhegorzhevskii, Kirill V
• Muslimov, Albert R
• Bondarenko, Andrey B
• Lebedev, Maxim D
• Kuz'min, Ilya A
• Vashurin, Artur S
• Lepik, Kirill V
• Timin, Alexander S
• Rumyantsev, Evgeniy V

Titel

DDAO Controlled Synthesis of Organo-Modified Silica Nanoparticles with Encapsulated Fluorescent Boron Dipyrrins and Study of Their Uptake by Cancerous Cells

Ist Teil von

• Molecules (Basel, Switzerland), 2020-08, Vol.25 (17), p.3802

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The design of cargo carriers with high biocompatibility, unique morphological characteristics, and capability of strong bonding of fluorescent dye is highly important for the development of a platform for smart imaging and diagnostics. In this paper, BODIPY-doped silica nanoparticles were prepared through a "one-pot" soft-template method using a sol-gel process. Several sol-gel precursors have been used in sol-gel synthesis in the presence of soft-template to obtain the silica-based materials with the most appropriate morphological features for the immobilization of BODIPY molecules. Obtained silica particles have been shown to be non-cytotoxic and can be effectively internalized into the cervical cancer cell line (HeLa). The described method of synthesis allows us to obtain silica-based carriers with an immobilized fluorescent dye that provide the possibility for real-time imaging and detection of these carriers.