Details

Autor(en) / Beteiligte

• Fuloria, Neeraj Kumar
• Singh, Vijender
• Shaharyar, Mohammad
• Ali, Mohammad

Titel

Synthesis and antimicrobial evaluation of some new oxadiazoles derived from phenylpropionohydrazides

Ist Teil von

• Molecules (Basel, Switzerland), 2009-05, Vol.14 (5), p.1898-1903

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study a series ofnew1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity. Among the newly synthesized compounds, 1-(2-(4-(dimethylamino)phenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2a)and1-(2-(4-chlorophenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2b)were found to possess maximum activity against the tested strains of S. aureus and P. aeruginosa. It was concluded that para-substitution enhances the activity of synthesized oxadiazoles.