Details

Autor(en) / Beteiligte

• Shen, Shan
• Jiang, Xiaolong
• Scala, Federico
• Fu, Jiakun
• Fahey, Paul
• Kobak, Dmitry
• Tan, Zhenghuan
• Zhou, Na
• Reimer, Jacob
• Sinz, Fabian
• Tolias, Andreas S

Titel

Distinct organization of two cortico-cortical feedback pathways

Ist Teil von

• Nature communications, 2022-10, Vol.13 (1), p.6389-6389, Article 6389

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Neocortical feedback is critical for attention, prediction, and learning. To mechanically understand its function requires deciphering its cell-type wiring. Recent studies revealed that feedback between primary motor to primary somatosensory areas in mice is disinhibitory, targeting vasoactive intestinal peptide-expressing interneurons, in addition to pyramidal cells. It is unknown whether this circuit motif represents a general cortico-cortical feedback organizing principle. Here we show that in contrast to this wiring rule, feedback between higher-order lateromedial visual area to primary visual cortex preferentially activates somatostatin-expressing interneurons. Functionally, both feedback circuits temporally sharpen feed-forward excitation eliciting a transient increase-followed by a prolonged decrease-in pyramidal cell activity under sustained feed-forward input. However, under feed-forward transient input, the primary motor to primary somatosensory cortex feedback facilitates bursting while lateromedial area to primary visual cortex feedback increases time precision. Our findings argue for multiple cortico-cortical feedback motifs implementing different dynamic non-linear operations.