Details

Autor(en) / Beteiligte

• Oneda, Ester
• Liserre, Barbara
• Bianchi, Denise
• Rota, Luigina
• Savelli, Giordano 
• Zorzi, Fausto
• Zaniboni, Alberto

Titel

Diagnosis of Mixed Adenoneuroendocrine Carcinoma (MANEC) after Neoadjuvant Chemotherapy for Pancreatic and Gastric Adenocarcinoma: Two Case Reports and a Review of the Literature

Ist Teil von

• Case reports in oncology, 2019-05, Vol.12 (2), p.434-442

Ort / Verlag

Basel, Switzerland: S. Karger AG

Erscheinungsjahr

2019

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract involving both epithelial and neuroendocrine (NE) components, each of which represents at least 30% of the tumor. Because of the low frequency of this histotype, only a few cases have been described. In this report we discuss two cases treated with neoadjuvant chemotherapy: a pancreatic adenocarcinoma and a gastric adenocarcinoma. The histopathological specimens examined after surgery showed an additional NE component with a possible indication of the MANEC histotype. We hypothesize two possible explanations: tumor NE cells are more chemo-resistant than adenocarcinoma cells, and cytotoxic injury induces NE differentiation in tumor cells. The clinical significance and prognostic value of endocrine differentiation, however, remain controversial issues.