Journal of lipid research, 2016-02, Vol.57 (2), p.176-192
2016
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- Autor(en) / Beteiligte
- Titel
- Phosphatidylinositolphosphate phosphatase activities and cancer
- Ist Teil von
- Journal of lipid research, 2016-02, Vol.57 (2), p.176-192
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2016
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon their target cells following receptor occupation. Overactivation of these pathways has been implicated in a number of pathologies, in particular a range of malignancies. The tight regulation of signaling pathways necessitates the involvement of both stimulatory and terminating enzymes; inappropriate activation of a pathway can thus result from activation or inhibition of the two signaling arms. The focus of this review is to discuss, in detail, the activities of the identified families of phosphoinositide phosphatase expressed in humans, and how they regulate the levels of phosphoinositides implicated in promoting malignancy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2275eISSN: 1539-7262DOI: 10.1194/jlr.R059154Titel-ID: cdi_doaj_primary_oai_doaj_org_article_db40a123999845ddbc46189c896576b6
- Format
- –
- Schlagworte
- cancer, Gene Expression Regulation, Neoplastic, Humans, lipid kinases, Lipid Metabolism - genetics, Neoplasms - genetics, Neoplasms - metabolism, Neoplasms - pathology, phosphatases/lipid, Phosphatidylinositol 3-Kinases - genetics, Phosphatidylinositol 3-Kinases - metabolism, Phosphatidylinositol Phosphates - metabolism, Phosphatidylinositols - metabolism, phosphoinositide 3-kinase, phosphoinositides, Phosphoric Monoester Hydrolases - genetics, Phosphoric Monoester Hydrolases - metabolism, Signal Transduction, Thematic Review Series