Details

Autor(en) / Beteiligte

• Su, Xianbin
• Zhao, Linan
• Shi, Yi
• Zhang, Rui
• Long, Qi
• Bai, Shihao
• Luo, Qing
• Lin, Yingxin
• Zou, Xin
• Ghazanfar, Shila
• Tao, Kun
• Yang, Guoliang
• Wang, Lan
• He, Kun-Yan
• Cui, Xiaofang
• He, Jian
• Wu, Jiao-Xiang
• Han, Bo
• Yan, Bin
• Deng, Biao
• Wang, Na
• Li, Xiaolin
• Yang, Pengyi
• Hou, Shangwei
• Sun, Jielin
• Yang, Jean Y H
• Chen, Jinhong
• Han, Ze-Guang

Titel

Clonal evolution in liver cancer at single-cell and single-variant resolution

Ist Teil von

• Journal of hematology and oncology, 2021-02, Vol.14 (1), p.22-22, Article 22

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Genetic heterogeneity of tumor is closely related to its clonal evolution, phenotypic diversity and treatment resistance, and such heterogeneity has only been characterized at single-cell sub-chromosomal scale in liver cancer. Here we reconstructed the single-variant resolution clonal evolution in human liver cancer based on single-cell mutational profiles. The results indicated that key genetic events occurred early during tumorigenesis, and an early metastasis followed by independent evolution was observed in primary liver tumor and intrahepatic metastatic portal vein tumor thrombus. By parallel single-cell RNA-Seq, the transcriptomic phenotype of HCC was found to be related with genetic heterogeneity. For the first time we reconstructed the single-cell and single-variant clonal evolution in human liver cancer, and dissection of both genetic and phenotypic heterogeneity will facilitate better understanding of their relationship.