Details

Autor(en) / Beteiligte

• Caiazzo, Elisabetta
• Sharma, Malvika
• Rezig, Asma O.M.
• Morsy, Moustafa I.
• Czesnikiewicz-Guzik, Marta
• Ialenti, Armando
• Sulicka-Grodzicka, Joanna
• Pellicori, Pierpaolo
• Crouch, Simone H.
• Schutte, Aletta E.
• Bruzzese, Dario
• Maffia, Pasquale
• Guzik, Tomasz J.

Titel

Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis

Ist Teil von

• Pharmacological research, 2024-02, Vol.200, p.107050-107050, Article 107050

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Immune responses play a significant role in hypertension, though the importance of key inflammatory mediators remains to be defined. We used a systematic literature review and meta-analysis to study the associations between key cytokines and incident hypertension. We performed a systematic search of Pubmed/Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), for peer-reviewed studies published up to August 2022. Incident hypertension was defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg and/or the use of antihypertensive medications. Random effects meta-analyses were used to calculate pooled hazard ratios (HRs)/risk ratios (RRs) and 95% confidence intervals by cytokine levels (highest vs. lowest quartile). Only IL-6 and IL-1β levels have evidence allowing for quantitative evaluation concerning the onset of hypertension. Six studies (10406 participants, 2932 incident cases) examined the association of IL-6 with incident hypertension. The highest versus lowest quartile of circulating IL-6 was associated with a significant HR/RR of hypertension (1.61, 95% CI: 1.00 to 2.60; I2 =87%). After adjusting for potential confounders, including body mass index (BMI), HR/RR was no longer significant (HR/RR: 1.24; 95% CI, 0.96 to 1.61; I2 = 56%). About IL-1β, neither the crude (HR/RR: 1.03; 95% CI, 0.60 to 1.76; n = 2) nor multivariate analysis (HR/RR: 0.97, 95% CI, 0.60 to 1.56; n = 2) suggested a significant association with the risk of developing hypertension. A limited number of studies suggest that higher IL-6, but not IL-1β, might be associated with the development of hypertension. [Display omitted]