International journal of nanomedicine, 2020-01, Vol.15, p.8151-8166
2020
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- Autor(en) / Beteiligte
- Titel
- Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
- Ist Teil von
- International journal of nanomedicine, 2020-01, Vol.15, p.8151-8166
- Ort / Verlag
- New Zealand: Dove Medical Press Limited
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety of malignancies. Nevertheless, a large proportion of patients do not benefit from their treatment while they do suffer from severe adverse events related to the solvent or to the active compound. Cremophor EL and polysorbate 80 free formulations, conjugates, oral formulations and different types of drug delivery systems are some examples of the several attempts to improve the treatment with taxanes. In this review article, we discuss recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer. Targeting mechanisms of drug delivery systems and characteristics of the most commonly used taxane-containing drug delivery systems in the clinical setting will be discussed in this review.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1178-2013, 1176-9114eISSN: 1178-2013DOI: 10.2147/IJN.S272529Titel-ID: cdi_doaj_primary_oai_doaj_org_article_da2b094e68184f01a02aca51e7ee3acb
- Format
- –
- Schlagworte
- Angiogenesis, Angiotensin II, Animals, Antineoplastic Agents - administration & dosage, Antineoplastic Agents - therapeutic use, Cabazitaxel, Cancer, Cell division, Clinical medicine, Drug Carriers - administration & dosage, Drug Carriers - chemistry, Drug delivery systems, Drug Delivery Systems - methods, Humans, Ligands, nanomedicine, nanoparticle, Nanoparticles, Nanostructures - administration & dosage, Nanostructures - chemistry, Nanostructures - therapeutic use, Neoplasms - drug therapy, Peripheral neuropathy, Permeability, Pharmacokinetics, Prostate cancer, Review, Surface active agents, Surfactants, taxane, Taxoids - administration & dosage, Taxoids - pharmacokinetics, Taxoids - therapeutic use, Tumors