Details

Autor(en) / Beteiligte

• Dika, Emi
• Scarfì, Federica
• Ferracin, Manuela
• Broseghini, Elisabetta
• Marcelli, Emanuela
• Bortolani, Barbara
• Campione, Elena
• Riefolo, Mattia
• Ricci, Costantino
• Lambertini, Martina

Titel

Basal Cell Carcinoma: A Comprehensive Review

Ist Teil von

• International journal of molecular sciences, 2020-08, Vol.21 (15), p.5572

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Basal cell carcinoma (BCC) is the most common type of carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic and genetic factors. However, despite the progress in the field, BCC biology and mechanisms of resistance against systemic treatments have been poorly investigated. The aim of the present review is to provide a revision of BCC histological and molecular features, including microRNA (miRNA) dysregulation, with a specific focus on the molecular basis of BCC systemic therapies. Papers from the last ten years regarding BCC genetic and phenotypic alterations, as well as the mechanism of resistance against hedgehog pathway inhibitors vismodegib and sonidegib were included. The involvement of miRNAs in BCC resistance to systemic therapies is emerging as a new field of knowledge.